Genetics MCQs

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Which of these might be a possible treatment of cystic fibrosis caused by the most common genetic variant in CFTR, the cystic fibrosis chloride channel?

  • A. A drug the blocks the kinase activity of PERK?
  • B. A mutation in the residues of IRE1 that are autophosphorylated
  • C. A drug the blocks ERAD
  • D. A mutation in ATF6 the prevents its cleavage by proteases
  • Correct Answer: Option C

Which of these is not a function of IRE1?

  • A. Directly senses unfolded proteins
  • B. It is cleaved to produce a transcription factor that goes to the nucleus and upregulates chaperones
  • C. Promotes degradation of mRNA that is being translated at ribosomes docked on Sec61
  • D. Splices the XBP1 mRNA
  • Correct Answer: Option B

Which of the following is NOT a way to help relieve protein folding stress in the ER?

  • A. Decrease transcription
  • B. Increase chaperone synthesis
  • C. Increase lipid synthesis
  • D. All of the above help relieve protein folding stress
  • Correct Answer: Option D

Why is protein folding stress more of a problem in the ER than in the cytoplasm?

  • A. Because the ER can't start folding proteins until they come through the Sec61 translocon.
  • B. Because the ER has to make disulfide bonds and do glycosylation
  • C. Because the ER is a smaller compartment.
  • D. Because membrane proteins are harder to fold.
  • Correct Answer: Option C

The unfolded protein response (UPR) operates at which levels of regulation?

I. transcription initiation
II. mRNA decay
III. translational initiation
IV. protein degradation
  • A. I, III
  • B. I, II, III, IV
  • C. I, II
  • D. III, IV
  • Correct Answer: Option B

Which disease can be caused by too much ER stress?

  • A. Huntington's
  • B. Type II diabetes
  • C. Parkinson's
  • D. Alzheimer's
  • Correct Answer: Option B

Which of these diseases does not directly involve protein aggregation?

  • A. Type II diabetes
  • B. Parkinson's
  • C. Alzheimer's
  • D. Huntington's
  • Correct Answer: Option A

Proteins are properly folded with the assistance of

  • A. chaperones
  • B. ribozymes
  • C. Sec61 translocon
  • D. signal recognition particles (SRPs)
  • Correct Answer: Option A

If RNAi ultimately presents a ssRNA to pair with an mRNA, why doesn’t the single-stranded antisense RNA work to cause interference?

  • A. Because it is degraded by RNases
  • B. Because it isn't a substrate for the RISC complex
  • C. Because it won't get chopped down by Dicer.
  • D. The sense RNA also has a role in interference.
  • Correct Answer: Option B

Levels of which of the following are NOT usually decreased by dsRNA?

  • A. Pre-mRNA
  • B. Processed mRNA
  • C. Protein
  • D. All are decreased
  • Correct Answer: Option A